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Coronary artery disease is one of the most common cardiovascular disorders in the world, and it can be deadly. Traditional diagnostic approaches are based on angiography, which is an interventional procedure having side effects such as contrast nephropathy or radio exposure as well as significant expenses. The purpose of this paper is to propose a novel artificial intelligence (AI) approach for the diagnosis of coronary artery disease as an effective alternative to traditional diagnostic methods.

In this study, a novel ensemble AI approach based on optimization and classification is proposed. The proposed ensemble structure consists of three stages: feature selection, classification and combining. In the first stage, important features for each classification method are identified using the binary particle swarm optimization algorithm (BPSO). In the second stage, individual classification methods are used. In the final stage, the prediction results obtained from the individual methods are combined in an optimized way using the particle swarm optimization (PSO) algorithm to achieve better predictions.

The proposed method has been tested using an up-to-date real dataset collected at Basaksehir Çam and Sakura City Hospital. The data of disease prediction are unbalanced. Hence, the proposed ensemble approach improves majorly the F-measure and ROC area which are more prominent measures in case of unbalanced classification. The comparison shows that the proposed approach improves the F-measure and ROC area results of the individual classification methods around 14.5% in average and diagnoses with an accuracy rate of 96%.

This study presents a low-cost and low-risk AI-based approach for diagnosing heart disease compared to traditional diagnostic methods. Most of the existing research studies focus on base classification methods. In this study, we mainly investigate an effective ensemble method that uses optimization approaches for feature selection and combining stages for the medical diagnostic domain. Furthermore, the approaches in the literature are commonly tested on open-access dataset in heart disease diagnoses, whereas we apply our approach on a real and up-to-date dataset.